PubMed Gnther, T. et al. Oxidation of methane into valuable chemicals, such as C 2+ molecules, has been long sought after but the dilemma between high yield and high selectivity of desired products remains. Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. It can take several minutes for a query to complete, and if youre using a lot of data the whole table may be locked up. Ancient human genomes suggest three ancestral populations for present-day Europeans. Furthermore, the gene pool of the western Gravettian populations is found continuously for at least 20,000 years: their descendants who are associated with the Solutrean and Magdalenian cultures stayed in southwestern Europe during the coldest period of the last Ice Age (between 25,000 and 19,000 years ago) and later spread north-eastward to the rest of Europe. This free online conference is featuring panel discussions from Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers. Tina Huang Profile page. It encourages me to go out and re-learn SQL and excites me for the mock interviews to come. NEWSLETTER: https://tinahuang.substack.com/ It's about learning, coding, and generally how to get your sh*t together c: I've been a FAANG data scientist f. Questions? Protoc. Inconsistent haplogroup assignments were manually verified as indicated24 (Supplementary Data 1.L). To mark the occasion, rather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. Its not clear if shell compete for a spot on the top 200, but I bet shell be there. I help students become independent data scientists who are not just good at data analysis, but are also able to think about their own learning and the world around them. & Fennema, K. Hunters of the Golden Age: The Mid Upper Palaeolithic of Eurasia, 30,000-20,000 bp (Univ. Tina Huang is a well-known data scientist who has over 10 years of experience on YouTube and has previously worked at a FAANG organization. The previously described Vstonice cluster, including a newly reported 29,000-year-old individual from Paglicci cave (Paglicci 12) in southern Italy, is closely related to the previously published genomes from Sunghir and Kostenki 12 in western Russia, which are dated to 34ka and 32ka, respectively4,23. Great content - Tina is all class and an excellent instructor. DNA analysis of an early modern human from Tianyuan Cave, China. Individuals with at least one library showing Y/Auto ratio > 0.2 were determined as maleindividuals, and with Y/Auto < 0.2 were determined as femaleindividuals4 (Supplementary Fig. CAS Purchasing this course makes it your own. TV Actresses. Advanced Science: Vol 10, No 7 - onlinelibrary.wiley.com As a Graduate and Consultant in the Business Tax Advisory (Financial Services) team, I provided tax advice and tax compliance services to organisations in the banking and capital markets, wealth and . Liet. In our interview with Tina Huang we were told the story of a student who wanted to learn to code. 18 and Supplementary Data 2.O), suggests the Balkans as a source of the incoming Epigravettian-associated population. Article Corporate Financial Managementspring term (BS 2508) Second year of undergraduate. Our analyses demonstrate that the Fournol cluster is a better source for Magdalenian-associated genomes than Goyet Q116-1. The expansion of farming by9,8, 7.5 and7 kais shown as green shades. Thank you for visiting nature.com. The Gravettian from a palaeodemographic point of view. Damgaard, P. et al. Great explanations and feels like real interviews that helps me warm up myself before the real interview! Notably, the Fournol ancestry provides a better proxy than Goyet Q116-1 for the genetic component found in the GoyetQ2 cluster and in El Mirn (Supplementary Data 2.H). Samples with a percentage of human DNA in shotgun data around 0.1% or greater were enriched for a set of 1,237,207 targeted SNPs (1240k capture) across the human genome6. Tina Huangis a data scientist currently working at a large FAANG enterprise. & Strimmer, K. APE: analyses of phylogenetics and evolution in R language. Evol. 41 Year Olds. Furthermore, we examined whether the patient's age, the etiology of their hearing loss, the depth of the electrode insertion, and a slow electrode insertion affect the result of postoperative speech audiometry (PSA). Ive always liked the idea of using data to make predictions. Meyer, M. & Kircher, M. Illumina sequencing library preparation for highly multiplexed target capture and sequencing. Data Engineer Cover Letter Sample and Template. Tina Huang - YouTube I hold a Bachelors degree at the University of Toronto where I studied pharmacology. 2, 17561762 (2007). Reviews. 4a). This is first detected in an individual from Gross Fredenwalde in northeastern Germany and reaches around 10% in most European hunter-gatherer individuals thereafter (Extended Data Fig. We further modelled the genetic profile of pre-LGM individuals with qpGraph (Supplementary Information, section10 and Supplementary Figs. Reducing microbial and human contamination in DNA extractions from ancient bones and teeth. Join a growing community of 11K+ to find accountability partners, take part in productivity sprints, and join discord only events! The dimensions are calculated using newly reported and previously published hunter-gatherer groups or individuals with more than 30,000 SNPs. This often involves analyzing similar products to compare how they performed. The human remains were processed in dedicated laboratories at the Max Planck Institute for the Science of Human History in Jena (Germany), University of Tbingen (Germany), University of Florence (Italy), Leiden University Medical Center (the Netherlands) and University of Tartu (Estonia). Dismiss. 6 Easy Ways to Support (Boost) Your Immune System Naturally We did not correct the calibrated dates for marine or freshwater reservoir effects but, when available, we report individual stable isotope values (15N/13C and C:N ratio) in Supplementary Data 1.A to evaluate the potential impact of such reservoir effects. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness . The pairwise f2 distance matrix of Epigravettian-associated groups was generated with qpfstats 200 in ADMIXTOOLS 7.0.2 package, with parameters allsnps: YES, scale: NO, and Mbuti.DG set as the outgroup. I hope youve enjoyed reading this article. Tina_Huang_Resume_i.pdf - Tina Huang hellotinah@gmail.com Dr. Huang taught General Chemistry, Quantitative Analysis, and Instrumental Methods for eight years at . tina huang data scientist The baseline of each population was determined using the average heterozygosity rate of individuals estimated from pseudo-diploid genotypes (Supplementary Data 1.E). Check out The data science resume that got me my FAANG job and subscribe to Tina Huangs YouTube channel. Disease-modifying, readily available, and easily affordable medical therapies for hypertension are ubiquitous and set a high bar for any new therapeutic. Surprisingly, however, none of those pre-40ka individuals left substantial traces in the genetic makeup of present-day Eurasian populations1,2,6,7. 211 and Supplementary Table 1). Finally, we estimated the genetic diversity of Epigravettian-associated individuals in the dataset by calculating both pairwise mismatch rates (PMR) on pseudo-haploid genotypes and individual heterozygosity levels on pseudo-diploid genotypes (Supplementary Data 3.A). The youngest individual carrying large portions of hunter-gatherer ancestry in the analysed dataset is from Ostorf in northern Germany, dated to around 5.2ka (>90% Oberkassel clusterplus Sidelkino-clustercomponents)(Supplementary Data 3.F). On the basis of PCA and outgroup f3-statistics, the Neolithic Tutkaul 1 individual from Tajikistan is closely related to Upper Palaeolithic individuals from south-central Siberia (Afontova Gora 3 (AG3) and Malta 1), and roughly contemporaneous West Siberian hunter-gatherers (Tyumen and Sosnoviy), both carrying high proportions of ANE ancestry45 (Fig. First up is the MIT researcher and YouTuber Jordan Harrod. I hope you brings out more courses like these. View Tina Huang's profile on LinkedIn, the world's largest professional community. 771234-PALEoRIDER (to W.H. On the basis of the genetic variation of present-day Europeans, this could imply phenotypic differences between post-14ka hunter-gatherer populations across Europe, with individuals in the Oberkassel cluster possibly exhibiting darker skin and lighter eyes, and individuals in the Sidelkino cluster possibly lighter skin and darker eye colour. R Programming in Data Science: High Variety Data SQL Server . We thus modelled individuals belonging to the GoyetQ2 cluster and El Mirn as a mixture between the Fournol 85 and Arene Candide 16 genomes as proxies to represent the Fournol and Villabruna ancestries, respectively, in Magdalenian-associated groups (Fig. Goutas, N. in Les Gravettiens (ed. With a lot of raw data, you need to put in some work. This affinity is even stronger towards Epigravettian-associated individuals from western and central Italy and Sicily (group 2 and group 3, respectively) than to those from northern Italy (group 1) (Supplementary Data 2.F). Wren, C. D. & Burke, A. Habitat suitability and the genetic structure of human populations during the Last Glacial Maximum (LGM) in Western Europe. & Nielsen, R. ANGSD: analysis of next generation sequencing data. 132, Tables 14 and references. Long-term Outcomes in Critically Ill Patients With COVID-19 in the Present-day individuals (gray dots) genotyped on theHumanOrigins dataset are used to define the PCA variation onto which ancient genomes (coloured symbols) are projected. Conversely,additional Oberkassel ancestry is identified in eastern Europe by at least 7.5ka in newly generated genomes from Minino I and Yazykovo from the upper Volga region, whereasa 1,000-years-older individual from Minino I did not have this genetic component. Her code challenge was titled Bias-Explained by Quantitative Data. Tina Huang (@hellotinah) Instagram photos and videos get subscribed to the Brandwatch Bulletin. 1c and Extended Data Fig. 1 and names are indicated next to the symbols. 71, 465492 (2015). 27, 576582 (2017). F-statistics suggest that Le Piage II is genetically intermediate between Fournol 85 and El Mirn (Supplementary Data 2.D). TV Actress. Article This was achieved through collaboration with local curators and scientists from the countries where the skeletal material is preserved and who are listed among the authors of this study. The genetic distinction between the Oberkassel and Sidelkino clusters is also clearly noticeable in the diversity of uniparentally inherited markers, as the Oberkassel cluster is dominated by mtDNA haplogroup U5 and Y-chromosome haplogroup I, whereas individuals from the Sidelkino cluster show a higher frequency of mtDNA haplogroups U2, U4 and R1b, and carry uniquely Y-chromosome haplogroups Q, R and J (Extended Data Figs. Our capabilities include CNC machining, sheet metal This might have been in part triggered by the concomitant expansion of Neolithic farmers across Europe and/or by environmental factors, such as the climatic event around 8.2ka, the largest abrupt cooling in the northern hemisphere during the Holocene epoch46,47. Financial support for ScienceDaily comes from advertisements and referral programs, where indicated. When Gravettian-associated individuals are included in an admixture graph also featuring Kostenki 14, we find that Fournol 85 fits best as a sister lineage of Goyet Q116-1, whereas the Vstonice group is modelled as a mixture between a lineage related to the Sunghir group and one related to the Goyet Q116-1Fournol 85 branch (Fig. Data warehousing is a relatively new field that focuses on the use of large datasets for analytical purposes. Nat. We further validated the genetic distinction between the Vstonice and Fournol clusters observed in the MDS plot with a series of f4-statistics (Supplementary Data 2.B). English company number 3898053New York | Boston | Chicago | Austin | Toronto | Brighton | London | Copenhagen | Berlin | Stuttgart | Frankfurt | Paris | Madrid | Budapest | Sofia | Chennai | Singapore | Sydney | Melbourne. 13, 24472461 (2018). Le palolithique suprieur en Italie. Develped strategies for promoting G-Mark to Taiwan. Taiwan Patent Application M401603, filed 11th April . Dotted lines delimit geographic regions described in the text. Sci. My name is Tina Huang and Im a data scientist at a FAANG company. Then we merged the genotypes from different libraries of the same individual, by randomly picking alleles from available genotype calls, using a custom script. These European regions, therefore, constitute climatic refugia where human populations survived during the LGM. Tina Huang is very empowering, and she knows what she is talking about. PubMed Central eLife 11, e77625 (2022). Details on individuals involved in the analysis, read counts processing and allele frequency computation are provided in the Supplementary Information, section12 and Supplementary Data 1.J and 3.G. Ace the SQL part of any data science job interview and get hired. However, published Gravettian-associated genomes originate from central and southern Europe, leaving the genetic profile of Gravettian-associated humangroups from western and southwestern Europe undescribed. Tina Huang. 12). 3b). Korneliussen, T. S., Albrechtsen, A. ), no. Similarly, the SMS spam collection data achieves 99.20% for the validation and 99.10% for testing. Tina is a computer science student at Stanford University. Its also hard to predict whats going to happen, but I hope its interesting to people who want to learn more about data science. Tina Huang | Data Scientist | Udemy PLoS Biol. W jednej z historii misiaczki za rad pewnej wydry zamieszkuj w tajemniczym domostwie. In the first place, we have traditional analysis. The MySQL engine is also known for being extremely slow compared to others. Article PubMed Opin. Mayra Alexandra Castrosqui - Quantitative Analyst - LinkedIn Double-stranded DNA libraries were built from 25l of DNA extract, without the presence of uracil DNA glycosylase (ds_nonUDG) or in the presence of uracil DNA glycosylase (ds_halfUDG), following a double-stranded UDG-half library preparation to reduce, but not eliminate, the amount of deamination-induced damage towards the ends of ancient DNA (aDNA) fragments58. The latter was created as a support network for women in the industry to discuss, share, and learn from each other.. In no time, she established herself as one of the favorite vloggers of the data community. Trzej niedwiedzi braciszkowie przeywaj swoje dziecistwo, pakujc si w najrozmaitsze tarapaty za spraw magicznego pudeka. Nat. Sci. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe. Bioinformatics 25, 20782079 (2009). 14, evac045 (2022). Harris, K. & Nielsen, R. The genetic cost of Neanderthal introgression. However, additional genomes intermediate in time and space are needed to assess whether those two admixture events were independent or part of a common demographic process. Her advice appears very solid, and she knows about the difficulties and barriers students are faced often when preparing for job interviews. The colours correspond to the grouping of tested populations, dots refer to the f4-values and the dark and light error bars to 1*SE and 3*SE estimated from 5 cM block jackknife, respectively. By co-analysing previously published data with our newly reported genomes associated with the Magdalenian from La Marche (18ka) and Pincevent (15ka) in western and northern France, respectively, and Maszycka (1816ka) in southern Poland, we confirm that the Goyet Q116-1 ancestry survived in all studied Magdalenian-associated genomes besides in Gravettian and Solutrean-associated individuals from southwestern and western Europe (Fig. We can have either structured data (e.g. 6). Large-scale genomic analysis documents the migrations of Ice Age hunter-gatherers over a period of 30,000 years -- they took shelter in Western Europe but died out on the . wrote the manuscript with input from T.T., E.A., W.H., J. Krause and all other co-authors. Subsequently, I worked in . In our case, we had data about people who had fallen off the internet, and we wanted to predict the probability that they would fall off at a certain time. It involves lots of hypothesis testing and statistics which 365 Data Science also has a wonderful course on. First Name Tina. PubMed Nature 570, 182188 (2019). The Gravettian culture was one of the most widely distributed Upper Palaeolithic cultures across western Eurasia before the LGM19. No need to do it alone our community of learners and instructors is there for you. Learn with a sense of purpose. and J.Krause performed or supervised genetic analyses. 5 Summary of ROH segments detected in Eurasian hunter-gatherers. Remember, its the problem that defines the tools we use! I think its cool to see a project like this happen and I hope its interesting for people to learn more about how this stuff works. PubMed Paleogenomic evidence for multi-generational mixing between Neolithic farmers and Mesolithic hunter-gatherers in the Lower Danube Basin. Home Courses Scoreboard Recommendations. Shes currently at Microsoft. One-time payment. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period3. Consistent with previous findings, none of the analysed groups show the derived allele at SNP rs4988235 on the LCT gene, which is responsible for lactase persistence.

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