With a total of 43,739 citations and 16,208 keywords, these articles were contributed by 5503 authors. Yuetian Y., Yujie L., Zhongheng Z., Zhichun G., Han Z., Qiongfang Z., Luyu Y., Cheng Z., Erzhen C. A bibliometric analysis using VOSviewer of publications on COVID-19. Curcumin improves wound contraction during. Curcumin and its analogues: Potential anticancer agents. To meet the increased need of energy, especially during the proliferative phase, wounds also metabolize carbohydrates and fats [26], which in turn are necessary for fibroblast and leukocyte activities, secretion of hormones and growth factors, and structural functions [29,30]. During collagen synthesis, vitamin C forms extra-bounds between collagen fibers that increase stability and strength of collagen matrix [8]. In wounds, it protects against the risk of infectious and inflammatory complications by up-regulating the expression of heat shock proteins [40]. Scope and approach: To evaluate the influence and significance of the countries, journals, organizations and authors that have contributed the most to this topic, the popular bibliometric markers, including article count, citation count, and Hirsch index (H-index), are taken into account. This is evident from the sharp rise of keywords such as electrospinning techniques, hydrogels, biocompatibility, biomechanics, chitosan, nano pharmaceutics, nanocomposites, emulsion and biomaterial. Liposomal carrier, nanocapsule and micelles are some of the other drug delivery vehicles used with curcumin [32,33,34,35,36]. The first ones consist of the presence of foreign bodies, tissue maceration, ischemia, and infection. The top 5 authors ranked by their H-index were Aggarwal B.B. In general, NF-B is physiologically inactivated by binding to its inhibitor IB. Blass S.C., Goost H., Tolba R.H., Stoffel-Wagner B., Kabir K., Burger C., Stehle P., Ellinger S. Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: A PRCT. Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1. These findings cumulatively suggest that nutritional approaches might be useful in the treatment of wounds, especially of chronic non-healing wounds [10]. Although curcumin does not seem to be involved in the migration of fibroblasts to the wound area in vitro [17], an in vivo study has suggested that curcumin mediates the infiltration of fibroblasts into wound sites, which in turn naturally differentiates into myofibroblasts during the formation of granulation tissue [82]. As a result, 320 keywords remained, arranged into 5 clusters with 23,481 links (Figure 5). We observed faster wound closure of punch wounds in curcumintreated animals in . As discussed below, curcumin also plays a critical role during the proliferative phase. The International Journal of Biological Macromolecules stands out as the most prolific publication source, having the most articles published (44) and also the most citations (2012), followed by the Journal of Ethnopharmacology (28 articles) and Current Pharmaceutical Design (20 articles), with 1231 and 812 citations, respectively. [(accessed on 1 January 2019)]; Katsarou A., Gudbjrnsdottir S., Rawshani A., Dabelea D., Bonifacio E., Anderson B.J., Jacobsen L.M., Schatz D.A., Lernmark . Curcumin-induced angiogenesis hastens wound healing in diabetic rats. The most central and highly weighted keywords in this network are likely to represent research hotspots in this active field, with a further need for curcumin in wound-healing research pertaining to these topics and the associated research directions. Moreover, it also exerts antioxidant effects by restoring the imbalance between ROS production and antioxidant activity [74,75,76,77,78,79,80]. Curcumin in Wound HealingA Bibliometric Analysis - MDPI Meiyanto, Edy is placed first with 9 articles, followed by Sahebkar, Amirhossein and Jenie, Riris with 8 and 7 articles published, respectively, on curcumin as a wound-healing agent. These keywords not only demonstrate the current research directions but also suggest that a variety of techniques are being employed to use curcumin in healing acute as well as chronic wounds. sharing sensitive information, make sure youre on a federal The academic influence of a country can be assessed by the total number of citations it receives. Turmeric ( Curcuma longa, diabetic ulcers, anorexia, cough and sinusitis. In the inflammatory phase, it participates in the recruitment of cells to the wound and their transformation into macrophages [29]. On the subject of curcumins ability to treat wounds, 159 different journals published a total of 1284 articles from 98 different nations and 3658 different organizations. Meshram M.G., Kale B., Revankar R.P., Jadhav V.V. Dermal wound healing is subject to redox control. One of the most investigated substances with pleiotropic effects in treating skin disorders is curcumin, the active ingredient of the medicinal plant Curcuma longa. This controversy might be due to difficulties in creating an in vitro model of fibroblast migration in wounds. Using the VOSviewer software, the gathered data was analyzed [37,38]. Sidhu G.S., Mani H., Gaddipati J.P., Singh A.K., Seth P., Banaudha K.K., Patnaik G.K., Maheshwari R.K. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Iyer V., Pumiglia K., DiPersio C.M. Asai A., Miyazawa T. Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma. An effective metric for assessing research collaboration is the level of academic cooperation [26]. Received 2019 Jan 25; Accepted 2019 Mar 1. Mohanty C., Das M., Sahoo S.K. Malnutrition is a common risk factor that might contribute to impaired wound healing [7,8,9]. Nagini S., Nivetha R., Palrasu M., Mishra R. Nimbolide, a neem limonoid, is a promising candidate for the anticancer drug arsenal. Beyond proteins, both carbohydrates and fats address increased energy needs to support inflammatory response, cellular activity, angiogenesis, and collagen deposition in the proliferative phase of healing process [26]. Reddy A.C., Lokesh B.R. Afterwards, the names of authors and their corresponding institutions and countries/regions were extracted from the author addresses. Curcumin (diferuloylmethane) is the main curcuminoid present in turmeric and responsible for its yellow color. ; resources: D..M. When the co-occurrence analysis of the authors keyword was conducted, a total of 3143 keywords appeared (Figure 7). Download Free PDF. To date, most of the current knowledge on wound healing derives from in vitro and in vivo studies, while epidemiological investigations are scarce. In line with these findings, Phan and colleagues have revealed the protective role of curcumin against hydrogen peroxide in keratinocytes and fibroblasts [80]. First, the majority of them are either brief reviews or systematic reviews [19,20,21,22,23]. With 32 collaborators, India came in second position, ahead of Iran (29), Italy (27), and China (23). An in vivo study has suggested that curcumin mediates the infiltration of fibroblasts into wound sites, which in turn naturally differentiates into myofibroblasts during the formation of granulation tissue [82]. The https:// ensures that you are connecting to the In 23 publications, China placed first among the USs collaborating partners, followed by India (22) and Iran (18). Curcumin in Wound HealingA Bibliometric Analysis. H Wound healing . Hence, vitamin B deficiencies indirectly affect the wound healing process by impairing antibody production and white blood cell function, which in turn increase the risk of infectious complications [49]. Theilla M., Schwartz B., Cohen J., Shapiro H., Anbar R., Singer P. Impact of a nutritional formula enriched in fish oil and micronutrients on pressure ulcers in critical care patients. Although zinc supplementation of 40220 mg/day for 1014 days [57] might be useful in zinc-deficient patients, its benefits in non-deficient patients are currently under debate [9]. Kant V., Gopal A., Kumar D., Pathak N.N., Ram M., Jangir B.L., Tandan S.K. Miranda M.R.H., Narayana Charyulu R., Jose J., Sandeep D.S. We also used the search string cur-cum*, which ensures that curcumin as well as curcuma longa are included in the results. Cutaneous wound healing: recruiting developmental pathways for regeneration. Recently, various topical formulations of curcumin such as films, fibers, emulsion, hydrogels and different nanoformulations have been developed for targeted delivery of curcumin at wounded sites. Vitamin C is essential to counteract the production of free radicals in damaged cells, while its deficiency might increase the fragility of new vessels [50]. Disclaimer/Publishers Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). However, to what extent they support wound healing process remains unclear until now. Curcumin, Aloe-vera and Ginger are popular natural medications (NMs) for treating wounds, however, the mechanisms by which these NMs apparently accelerate wound healing remain largely unknown. The importance of dietary protein in healing pressure ulcers. Physiologically, wound healing consists of three phases: Inflammation, proliferation, and remodeling or maturation [3]. Consequently, 1284 journal articles were selected for the bibliometric analyses. Carbohydrates also stimulate secretion of hormones and growth factors, including insulin that is helpful in the anabolic processes of the proliferative phase. Recent trends on wound management: New therapeutic choices based on polymeric carriers. The academic level was also measured using the H-index from both a quality and a quantity perspective. Zhang Y., Liu Z., Wu J., Bai B., Chen H., Xiao Z., Chen L., Zhao Y., Lum H., Wang Y., et al. While acute wounds show a linear progression of these overlapping events, the progression in chronic wounds does not occur in synchrony, with some areas being in different phases at the same time [15]. Velnar T., Bailey T., Smrkolj V. The wound healing process: An overview of the cellular and molecular mechanisms. Although anti-oxidant enzymes (i.e., superoxide dismutase, glutathione peroxidase, and catalase) protect cells against toxic ROS levels [73], the imbalance between ROS concentrations and antioxidant activity could determine chronic diseases. Based on our search and to the best of our knowledge, this is the first bibliometric review on the topic; hence, it is envisaged that it will encourage researchers to explore future research dimensions in the related field. Molnar J.A., Underdown M.J., Clark W.A. Singer A.J., Clark R.A. Cutaneous wound healing. The terms cell proliferation, antineoplastic activity, anti-inflammatory, and gene expression regulation are among those found in the yellow cluster and are all related to the properties of curcumin. Hence, implications of weight loss and decreased lean body mass should be recognized when considering the effect of protein-calorie deficiency on the healing process. Falanga V. The chronic wound: Impaired healing and solutions in the context of wound bed preparation. This has led to widespread use of numerous plants and their derivatives in the Asian and African subcontinents. Molecules. Moreover, it contributes to the production and activity of antioxidant enzymes [77,78] and their constituents, such as glutathione (GSH) [79]. Trujillo E.B. Role of arginine in superficial wound healing in man. The results collected can serve as a guide for those wanting to make contributions to this field by providing details about active journals, authors, and widely researched topics in this area. How to conduct a bibliometric analysis: An overview and guidelines. Curcumin in Wound HealingA Bibliometric Analysis - PMC Despite strides which have been made in the formulation of curcumin for topical application at the wound site [74,83,84,85,101], further research is recommended to improve curcumin delivery and to evaluate its effects in wound patients. ; formal analysis: F.F., S.S.S. the contents by NLM or the National Institutes of Health. Additionally, it dramatically lowers the expression of antioxidant enzymes, one of the primary causes of inflammation and the oxidation process [15]. Among the curcuminoids, curcumin is the powerful substance which possesses anti-inflammatory, analgesic and wound healing properties 13, 14 . Curcumin as potential therapeutic natural product: a Since curcumin induces apoptosis of inflammatory cells during the early phase of wound healing, it could also accelerate the healing process by shortening the inflammatory phase. Staphylococcus aureus (MRSA) bacteria can infect numerous body parts. Scope and approach: To evaluate the influence and significance of the countries, journals, organizations and . Russell L. The importance of patients nutritional status in wound healing. In conclusion, we support the notion that curcumin could be considered as a wound healing agent, especially if topically administered. This is due to new drug formulation methods and incorporation of bioengineering and biotechnology approaches. The second ones include aging, malnutrition, diabetes, and renal diseases. A co-occurrence network was generated based on the authors as well as overall keywords. Beyond that, fibrin plug also provides an extracellular matrix for cell migration [2] and releases growth factors (e.g., platelet-derived growth factorPDGFand transforming growth factorTGF) involved in the recruitment of cells to the wound [1,2]. The majority of institutions, including Shahid Beheshti University of Medical Sciences, the Ministry of Education of China, and the Central Leather Research Institute of India, demonstrated an increase in interest in the field when comparing the annual productivity. Wound healing is the property of living organisms, which re-sists a state of entropy to resume function and maintain life.Healing of wounds is a chain of process necessary for the re-moval of invaded pathogens from the damaged tissue of thebody and for complete or partial remodeling of injured tis-sues. Conceptualization, A.M., M.B., A.A. and G.B. Li H.Y., Yang M., Li Z., Meng Z. Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR- activity and reducing oxidative stress. In acute woundscutaneous injuries that do not have an underpinning pathophysiological defectthe main evolutionary force may have been to achieve repair quickly and with the smallest amount of energy [2]. This review summarizes and discusses recently published papers on the effects of curcumin on skin wound healing. Wu G., Bazer F.W., Davis T.A., Kim S.W., Li P., Marc Rhoads J., Carey Satterfield M., Smith S.B., Spencer T.E., Yin Y. Arginine metabolism and nutrition in growth, health and disease. Meiyanto, E., and Jenie, R.I. are the second most collaborative partners with a link strength of 12. Then the Cur/PCEC nanoparticles were incorporated with collagen and PVA to build a composite film used as a wound . Background: Curcumin has been widely used to treat a variety of diseases and disorders since ancient times, most notably for the purpose of healing wounds. In the proliferative and remodeling phases, protein-energy deficiency may also decrease fibroblast activity, delaying angiogenesis and reducing collagen formation [8]. ; methodology: S.S.S. Kalava U.R., Cha S.S., Takahashi P.Y. The natural medications for wound healing - Curcumin, Aloe-Vera and Overexpression of TRPM7 promotes the therapeutic effect of curcumin in PDF Evidence Summary: Turmeric (curcumin) in wound management (Limited In line with the Special Issue Curcumin in Health and Disease, we have focused on the beneficial effects of curcumin, which exerts its anti-inflammatory and antioxidant properties during the different phases of the wound healing process [11]. Curcumin: Total-Scale Analysis of the Scientific Literature. Nutrition and wound healing. Methicillin-resistant . The recent literature on the wound healing properties of curcumin also provides evidence for its ability to enhance granulation tissue formation, collagen deposition, tissue remodeling and wound contraction. Beyond macronutrients, several micronutrients play a crucial role in the wound healing process, as extensively reviewed [7,8,9,33]. When it comes to collaboration networks, the United States came out on top with the most (33 countries) in the world. 1Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Via S. Sofia 87, 95123 Catania, Italy; ti.tcinu@attihcrab.anitram (M.B. Before proceeding to the analyses, the following factors were first used to evaluate the publications retrieved through the search: (1) Number of publications per year; (2) Organization; (3) Countries/Regions; (4) Journals; (5) Total Citations; and (6) Keywords. sharing sensitive information, make sure youre on a federal By examining the interpersonal connections between various authors, countries and institutions, bibliometric analysis describes the bibliometric and intellectual framework of a particular field of interest [25]. The United States has a greater academic influence than the rest of the world, as evidenced by the highest number of citations (13,361), despite the fact that India provided the most articles (354 articles), accounting for more than 27.49 percent of the total corpus pertaining to curcumin and wound healing. One possible reason for this trend could be the strict rules governing the use of natural compounds like curcumin in USA. Despite strides in technological innovations of a wide range of treatments against wounds, non-healing wounds continue to challenge physicians. Welch M.P., Odland G.F., Clark R.A. Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction. Donthu N., Kumar S., Mukherjee D., Pandey N., Lim W.M. The font size of the words on the bubble map represents how frequently the terms occur (multiple appearances in a single publication count as one). Curcumin was widely utilized in traditional Indian . In fact, these patients often exhibit protein-energy malnutrition or specific vitamin and mineral deficiencies [8]. The most frequently used markers in bibliometric studiesarticle count, citation count and Hirsch index (H-index)were taken into consideration to measure the influence and impact of the scientific research conducted. ; writingreview and editing: F.S. Beyond micronutrients, arginine and glutamine, vitamin A, B, C, and D, zinc, and iron are essential for inflammatory process and synthesis of collagen. To name, firstly hemostasis driven by vasoconstriction and complementing cascades, secondly, inflammation driven by vasodilation and activation of macrophage.

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